Publications

Stéen EJL, Edem PE, Nørregaard K, Jørgensen JT, Shalgunov V, Kjaer A, Herth MM. Pretargeting in nuclear imaging and radionuclide therapy: Improving efficacy of theranostics and nanomedicines. Biomaterials 2018, 179, 209-245, doi: 10.1016/j.biomaterials.2018.06.021. Abstract

Svatunek D, Denk C, Mikula H. A computational model to predict the Diels–Alder reactivity of aryl/alkyl-substituted tetrazines. Chemical Monthly 2018, 4, 833-837, doi: 10.1007/s00706-017-2110-x. Abstract

Stéen EJL, Shalgunov V, Denk C, Mikula H, Kjær A, Kristensen JL, Herth MM. Convenient Entry to ¹⁸F-labeled Amines Through the Staudinger Reduction. European Journal of Organic Chemistry 2019, 2019, 1722-1725, doi: 10.1002/ejoc.201801457. Abstract

Rosecker V, Denk C, Maurer M, Wilkovitsch M, Mairinger S, Wanek T, Mikula H. Cross-Isotopic Bioorthogonal Tools as Molecular Twins for Radiotheranostic Applications. ChemBioChem 2019, 20: 1530-1535, doi: 10.1002/cbic.201900042. Abstract

Kramer S, Svatunek D, Alberg I, Gräfen B, Schmitt S, Braun L, van Onzen AHAM, Rossin R, Koynov K, Mikula H, Zentel R. HPMA-Based Nanuparticles for Fast, Bioorthogonal iEDDA Ligation. Biomacromolecules 2019, 20, 3786-3797, doi: 10.1021/acs.biomac.9b00868. Abstract

Denk C, Wilkovitsch M, Aneheim E, Herth MM, Jensen H, Lindegren S, Mikula H. Multifunctional clickable reagents for rapid bioorthogonal astatination and radio-crosslinking. ChemPlusChem 2019, 84, 775-778, doi: 10.1002/cplu.201900114. Abstract

Stéen EJL, Jørgensen JT, Petersen IN, Nørregaard K, Lehel S, Shalgunov, V, Birke A, Edem PE, L’Estrade ET, Hansen HD, Villadsen J, Erlandsson M, Ohlsson T, Yazdani A, Valliant JF, Kristensen JL, Barz M, Knudsen GM, Kjær A, and Herth MM. Improved radiosynthesis and preliminary in vivo evaluation of the ¹¹C-labeled tetrazine [¹¹C]AE-1 for pretargeted PET imaging. Bioorganic & Medicinal Chemistry Letters 2019, 29, 986-990, doi: 10.1016/j.bmcl.2019.02.014. Abstract

Stéen EJL, Jørgensen JT, Johann, K, Nørregard K, Sohr B, Svatunek D, Birke A, Shalgunov V, Edem PE, Rossin R, Seidl C, Schmid F, Robillard M, Kristensen JL, Mikula H, Barz M, Kjær A, and Herth MM. Trans-cyclooctene-functionalized PeptoBrushes with improved reaction kinetics of the tetrazine ligation for pretargeted nuclear imaging. ACS Nano 2020, 14, 568-584, doi: 10.1021/acsnano.9b06905. Abstract

Johann K, Svatunek D, Seidl, C, Rizelli, S, Bauer TA, Braun L, Koynov K, Mikula H, Barz M. Tetrazine- and trans-Cyclooctene-functional Polypept(o)ides for Fast Bioorthogonal Tetrazine Ligation. Polymer Chemistry 2020, 11, 4396-4407, doi: 10.1039/D0PY00375A. Abstract

Edem PE, Jørgensen JT, Nørregaard K, Rossin R, Yazdani A, Valliant JF, Robillard M, Herth MM, Kjaer A. Evaluation of a 68Ga-Labeled DOTA-Tetrazine as a PET Alternative to 111In-SPECT Pretargeted Imaging. Molecules 2020, 25, 463, doi:10.3390/molecules25030463. Abstract

Edem PE, Sinnes JP, Pektor S, Bausbacher N, Rossin R, Yazdani A, Miederer M, Kjaer A, Valliant JF, Robillard M, Rösch F, Herth MH. Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging. EJNMMI Research 2019, 9, 49, doi: 10.1186/s13550-019-0520-y. Abstract

Svatunek D, Wilkovitsch M, Hartmann L, Houk KN, Mikula H. Uncovering the key role of distortion in tetrazine ligations guides the design of bioorthogonal tools with reactivity and superior stability. ChemRxiv 2021, doi: 10.33774/chemrxiv-2021-vnwzk. Abstract

Garcıa-Vazquez R, Battisti U, Jørgensen JT, Shalgunov V, Hvass L, Stares DL, Petersen IN, Crestey F, Löffler A, Svatunek D, Kristensen JL, Mikula H, Kjaer A, Herth MM. Direct Cu-mediated aromatic 18F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging. Chemical Sci 2021 (advance article), doi: 10.1039/d1sc02789a. Abstract

Steen EJ, Jørgensen JT, Denk C, Battisti UM, Nørregaard K, Edem PE, Bratteby K, Shalgunov V, Wilkovitsch M, Svatunek D, Poulie CBM, Hvass L, Simón M, Wanek T, Rossin R, Robillard M, Kristensen JL, Mikula Hannes, Kjaer A, Herth MM. Lipophilicity and Click Reactivity Determine the Performance of Bioorthogonal Tetrazine Tools in Pretargeted In Vivo Chemistry. ACS Pharmacol Transl Sci 2021, 4,2, 824-833, doi: 1021/acsptsci.1c00007. Abstract

Bratteby K, Shalgunov V, Battisti U, Petersen IN, van den Broek SL, Ohlsson T, Gillings N, Erlandsson M, Herth MM. Insights into Elution of Anion Exchange Cartridges: Opening the Path toward Aliphatic 18 F‑Radiolabeling of Base-Sensitive Tracers. ACS Pharmacol Transl Sci 2021 (advance article), doi: 1021/acsptsci.1c00133. Abstract

Other (selected)

European Association of Nuclear Medicine (EANM) 2017

Invited speaker: M Robillard

Imaging and Therapy Agents Using Click Chemistry

European Symposium on Radiopharmacy and Radiopharmaceuticals 2018

Invited speaker: R Rossin

In Vivo Click Chemistry

Society of Nuclear Medicine & Molecular Imaging (SNMMI) 2018

J Stéen. Poster Award Winner, 3rd place in the session "Molecular Targeting Probes"

Towards the Dual Click ¹⁸F-Labeling of Antibodies. Abstract

Controlled Release Society (CRS) meeting 2019

Invited speaker: M Barz

Nanoparticles For Pretagergeted PET Imaging And Radionuclide Therapy: In Vivo Click Chemistry On Polymer Brushes

Targeted Radiopharmaceuticals Summit 2019

Invited speaker: M Robillard

In-Vivo Click Strategies for Antibody-Based Imaging and Radiotherapy

Radioanalytical and Nuclear Chemistry (RANC) 2019

Invited speaker: MM Herth

Pretargeted imaging

International Conference on Medicinal Chemistry 2019

Invited speaker: M Robillard

Click-Cleavable Antibody-Drug Conjugates